The disease characteristics of different strains of scrapie in Sinc congenic mouse lines: implications for the nature of the agent and host control of pathogenesis.

Abstract excerpt

Mouse lines which are congenic for Sinc, the major gene controlling scrapie incubation period, have been produced by selective breeding from the inbred C57BL(Sincs7) and VM(Sincp7) strains; the s7 allele of Sinc has been introduced into a VM background by 18 serial backcrosses, at each generation selecting on the basis of the incubation period with the ME7 scrapie strain. The characteristics of the disease...

Topics

• Alleles
• Animals
• Brain
• Crosses, Genetic
• Female
• Genotype
• Male
• Mice
• Mice, Inbred Strains
• Polymorphism, Restriction Fragment Length
• Prions