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Article

Genetics of prion diseases and prion diversity in mice.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Mar 1994

Carlson G A, DeArmond S J, Torchia M, Westaway D, Prusiner S B

Abstract excerpt

Linkage of the prion protein (PrP) and scrapie incubation time genes in mice provided strong evidence for the central role of PrP in determining susceptibility to prion disorders. Considerable evidence now argues that the prion protein and incubation time genes are identical. The mouse prion protein gene (Prn-p) may act both quantitatively and qualitatively in modulating prion incubation time. Differences at...

Topics

Animals
Disease Models, Animal
Genetic Linkage
Genetic Variation
Mice
Mice, Transgenic
Nerve Tissue Proteins
Neuromuscular Diseases
PrPSc Proteins
Prion Diseases
Prions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Scrapie

Source

Identifiers

PMID: 7913753
DOI: 10.1098/rstb.1994.0030

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7913753-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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