Replication of distinct scrapie prion isolates is region specific in brains of transgenic mice and hamsters.

doi:10.1101/gad.6.7.1213

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Article

Replication of distinct scrapie prion isolates is region specific in brains of transgenic mice and hamsters.

Genes & development - 1 Jul 1992

Hecker R, Taraboulos A, Scott M, Pan K M, Yang S L, Torchia M, Jendroska K, DeArmond S J, Prusiner S B

Abstract excerpt

Scrapie prions are composed largely, if not entirely, of PrPSc molecules. The prion isolates Sc237 and 139H exhibit markedly different incubation times in Syrian, Armenian, and Chinese hamsters, as well as in transgenic (Tg) 81 mice expressing Syrian hamster PrP (SHaPrP). Repassage of prions from...

Topics

Animals
Animals, Genetically Modified
Brain
Cricetinae
Kinetics
Mesocricetus
Mice
Mice, Transgenic
Phenotype
Prions
Scrapie
Serial Passage
Vacuoles
Virus Replication

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