Article
Vacuolization, incubation period and survival time analyses in three mouse genotypes injected stereotactically in three brain regions with the 22L scrapie strain.
Journal of neuropathology and experimental neurology - 1 Mar 1990
Kim Y S, Carp R I, Callahan S M, Natelli M, Wisniewski H M
Abstract excerpt
In previous studies we showed that C57BL mice injected stereotactically in the cerebellum with the 22L scrapie strain had a significantly shorter incubation period than those injected with the same agent in other brain regions. In mice injected in the cerebellum, vacuolization was limited to the cerebellum, medulla and mesencephalon, whereas injection into forebrain regions resulted in vacuolization in all brain...
Topics
- Animals
- Brain
- Genotype
- Injections
- Mice
- Mice, Inbred C57BL
- Prions
- Scrapie
- Stereotaxic Techniques
- Survival Analysis
- Time Factors