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Article

Sod1 deficiency reduces incubation time in mouse models of prion disease.

PloS one - 1 Jan 2013

Akhtar Shaheen, Grizenkova Julia, Wenborn Adam, Hummerich Holger, Fernandez de Marco Mar, Brandner Sebastian, Collinge John, Lloyd Sarah E

Abstract excerpt

Prion infections, causing neurodegenerative conditions such as Creutzfeldt-Jakob disease and kuru in humans, scrapie in sheep and BSE in cattle are characterised by prolonged and variable incubation periods that are faithfully reproduced in mouse models. Incubation time is partly determined by genetic factors including polymorphisms in the prion protein gene. Quantitative trait loci studies in mice and human...

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Identifiers

PMID: 23349894
DOI: 10.1371/journal.pone.0054454
PMCID: PMC3551847

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MRC2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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