Article
Identification and characterization of a novel mouse prion gene allele.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 May 2004
Lloyd Sarah E, Thompson Simon R, Beck Jonathan A, Linehan Jacqueline M, Wadsworth Jonathan D F, Brandner Sebastian, Collinge John, Fisher Elizabeth M C
Abstract excerpt
The major determinant of prion disease incubation time in mice is thought to be the amino acid sequence of the prion protein. Two alleles of the mouse prion gene ( Prnp) have been described, where Prnp(a) (Leu-108, Thr-189) and Prnp(b) (Phe-108, Val-189) are associated with short and long incubation times, to defined prion strains, respectively. As part of a survey of inbred mouse lines, the prion gene open...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.