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Article

Host Determinants of Prion Strain Diversity Independent of Prion Protein Genotype.

Journal of virology - 1 Oct 2015

Crowell Jenna, Hughson Andrew, Caughey Byron, Bessen Richard A

Abstract excerpt

UNLABELLED: Phenotypic diversity in prion diseases can be specified by prion strains in which biological traits are propagated through an epigenetic mechanism mediated by distinct PrP(Sc) conformations. We investigated the role of host-dependent factors on phenotypic diversity of chronic wasting disease (CWD) in different host species that express the same prion protein gene (Prnp). Two CWD strains that have...

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Identifiers

PMID: 26246570
DOI: 10.1128/JVI.01586-15
PMCID: PMC4580196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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