Mice with gene targetted prion protein alterations show that Prnp, Sinc and Prni are congruent.

doi:10.1038/ng0298-118

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Article

Mice with gene targetted prion protein alterations show that Prnp, Sinc and Prni are congruent.

Nature genetics - 1 Feb 1998

Moore R C, Hope J, McBride P A, McConnell I, Selfridge J, Melton D W, Manson J C

Abstract excerpt

Classical genetic analysis has identified Sinc/Prni as the major gene controlling mouse scrapie incubation time. Sinc/Prni is linked to Prnp, the gene encoding the prion protein (PrP). Prnp alleles express distinct PrP protein variants, PrP A and PrP B, which arise from codon 108L/F and 189 T/V d...

Topics

Alleles
Animals
Brain
Codon
Genetic Variation
Mice
Mice, Mutant Strains
Mice, Transgenic
Molecular Sequence Data
Point Mutation
Prions
Scrapie
Species Specificity

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