Article
Three scrapie prion isolates exhibit different accumulation patterns of the prion protein scrapie isoform.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jul 1993
DeArmond S J, Yang S L, Lee A, Bowler R, Taraboulos A, Groth D, Prusiner S B
Abstract excerpt
To investigate the molecular basis of prion diversity, we inoculated transgenic mice expressing the Syrian hamster prion protein (PrP) with three distinct prion isolates. We compared the three isolates designated Sc237, 139H, and Me7H in Tg(SHaPrP)7 mice with clinical signs of scrapie because the...
Topics
- Animals
- Brain
- Cricetinae
- Genetic Variation
- Immunohistochemistry
- Mesocricetus
- Mice
- Mice, Transgenic
- PrPSc Proteins
- Prions
- Scrapie
- Tissue Distribution