Article
Effect of Sinc genotype, agent isolate and route of infection on the accumulation of protease-resistant PrP in non-central nervous system tissues during the development of murine scrapie.
The Journal of general virology - 1 Mar 1994
Farquhar C F, Dornan J, Somerville R A, Tunstall A M, Hope J
Abstract excerpt
Mice congenic for the Sinc gene were infected intracerebrally with two scrapie strains, ME7 and 22A. At various times during the incubation period tissues were monitored for the infection-specific form of PrP (PrPSc). PrPSc was found in brain, spleen, lymph nodes, pancreas, submaxillary gland and...
Topics
- Animals
- Brain
- Disease Models, Animal
- Endopeptidase K
- Genotype
- Kinetics
- Lymphoid Tissue
- Mice
- Mice, Inbred Strains
- Pancreas
- PrPSc Proteins
- Prions
- Scrapie
- Serine Endopeptidases