Article
Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jun 1994
Carlson G A, Ebeling C, Yang S L, Telling G, Torchia M, Groth D, Westaway D, DeArmond S J, Prusiner S B
Abstract excerpt
Different prion isolates, often referred to as "strains," present an enigma because considerable evidence argues that prions are devoid of nucleic acid. To investigate prion diversity, we inoculated three "strains" of prions into congenic and transgenic mice harboring variable numbers of two different alleles, designated a and b, of the prion protein (PrP) structural gene, Prn-p. The length of the incubation time...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.