Article
MHC-restricted recognition of autologous melanoma by tumor-specific cytotoxic T cells. Evidence for restriction by a dominant HLA-A allele.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1991
Crowley N J, Darrow T L, Quinn-Allen M A, Seigler H F
Abstract excerpt
Autologous melanoma-specific CTL recognize a common tumor-associated Ag (TAA) in the context of HLA class I antigens. We have demonstrated that HLA-A2 can be a restricting Ag and, in T cell lines homozygous for HLA-A2, that CTL can be generated by stimulation with HLA-A2 allogeneic melanomas. In the current study, we have investigated T cell lines from patients who are heterozygous at HLA-A region locus, to...
Topics
- Alleles
- Antigens, Neoplasm
- Cell Line
- HLA-A1 Antigen
- HLA-A2 Antigen
- Humans
- Isoantigens
- Melanoma
- Phenotype
- Polymorphism, Restriction Fragment Length
- T-Lymphocytes, Cytotoxic