Article
Binding and presentation of peptides derived from melanoma antigens MART-1 and glycoprotein-100 by HLA-A2 subtypes. Implications for peptide-based immunotherapy.
Journal of immunology (Baltimore, Md. : 1950) - 15 May 1996
Rivoltini L, Loftus D J, Barracchini K, Arienti F, Mazzocchi A, Biddison W E, Salgaller M L, Appella E, Parmiani G, Marincola F M
Abstract excerpt
Cellular immune responses to melanoma-associated Ags are the focus of ongoing studies aimed at developing immunotherapies for treatment of malignant melanoma. Melanoma predominantly affects Caucasians, a population in whom expression of HLA-A2 is prevalent. Among HLA-A2 subtypes, HLA-A*0201 is wi...
Topics
- Alleles
- Amino Acid Sequence
- Antigen Presentation
- Antigens, Neoplasm
- HLA-A2 Antigen
- Humans
- Immunotherapy, Adoptive
- Lymphocyte Activation
- MART-1 Antigen
- Melanoma
- Membrane Glycoproteins
- Molecular Sequence Data
- Neoplasm Proteins
- Peptides