Article
Quantitative correlation between HLA class I allele expression and recognition of melanoma cells by antigen-specific cytotoxic T lymphocytes.
Cancer research - 15 Jul 1995
Rivoltini L, Barracchini K C, Viggiano V, Kawakami Y, Smith A, Mixon A, Restifo N P, Topalian S L, Simonis T B, Rosenberg S A
Abstract excerpt
MHC class I antigen expression is necessary for CD8+ T-cell-mediated recognition of tumors. Recently, several mechanisms leading to loss or decreased expression of MHC antigens on the tumor cell surface have been described that may account for tumor escape from immune recognition. It is yet unkno...
Topics
- Alleles
- Amino Acid Sequence
- Antigens, Neoplasm
- Base Sequence
- Binding Sites
- CD8-Positive T-Lymphocytes
- Clone Cells
- Epitopes
- Gene Expression
- HLA-A2 Antigen
- Histocompatibility Antigens Class I
- Humans
- Kinetics
- Melanoma