Article
Affinity, specificity and T-cell-receptor diversity of melanoma-specific CTL generated in vitro against a single tyrosinase epitope.
International journal of cancer - 17 Sept 1997
Visseren M J, van der Burg S H, Hawes G E, van der Voort E I, van den Elsen P J, Melief C J
Abstract excerpt
MHC-class-I-restricted cytotoxic T lymphocytes (CTL) specific for tumor-associated antigens expressed by malignant cells are important components of the immune response against cancer. Recently, tumor-specific CTL could be generated in vitro, with responding lymphocytes from the blood of healthy...
Topics
- Amino Acid Sequence
- B-Lymphocytes
- Base Sequence
- Epitopes
- Genes, T-Cell Receptor alpha
- Genes, T-Cell Receptor beta
- Genetic Variation
- HLA-A Antigens
- Humans
- Melanoma
- Molecular Sequence Data
- Monophenol Monooxygenase
- Receptors, Antigen, T-Cell, alpha-beta
- T-Lymphocytes, Cytotoxic
- Tumor Cells, Cultured