Natural killer cell lines kill autologous β 2 -microglobulin-deficient melanoma cells: Implications for cancer immunotherapy

Abstract excerpt

Cancer vaccines used to generate specific cytotoxic T lymphocytes are not effective against tumor cells that have lost or suppressed expression of their class I major histocompatibility complex proteins. This loss is common in some cancers and particularly in metastatic lesions. We show that beta2-microglobulin-deficient class I-negative melanoma variants derived from patients undergoing specific T cell therapy...

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