Article
Novel HLA-Cw8-restricted T cell epitopes derived from tyrosinase-related protein-2 and gp100 melanoma antigens.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1999
Castelli C, Tarsini P, Mazzocchi A, Rini F, Rivoltini L, Ravagnani F, Gallino F, Belli F, Parmiani G
Abstract excerpt
The identification of T cell epitopes presented by alternative HLA-B and -C alleles may provide a means to counteract the tumor escape mechanism based on the selection of tumor cells no longer susceptible to HLA-A-restricted T cell recognition. Several T cell clones and lines were obtained from T...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Antigens, Neoplasm
- COS Cells
- Cell Line
- Cytotoxicity, Immunologic
- Epitopes
- HLA-B Antigens
- HLA-B14 Antigen
- HLA-C Antigens
- Humans
- In Vitro Techniques
- Intramolecular Oxidoreductases
- Melanoma
- Membrane Glycoproteins
- Neoplasm Proteins
- T-Lymphocytes