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Article

Reduced recognition of metastatic melanoma cells by autologous MART-1 specific CTL: relationship to TAP expression.

Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jan 2000

Murray J L, Hudson J M, Ross M I, Zhang H Z, Ioannides C G

Abstract excerpt

Class I expression in context with T-cell receptor expression is crucial for peptide presentation and induction of CD8+ cytotoxic T lymphocytes (CTL). Presentation of class I bound peptides is dependent on transporter-associated proteins (TAP) expression and function. Tumor infiltrating lymphocytes from a patient with melanoma were isolated, expanded in vitro in the presence of interleukin-2, and tested for...

Read the complete abstract on PubMed

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Share to Abdominal Neoplasms
Share to Antigens, Neoplasm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B, Member 2

Share to ATP Binding Cassette Transporter, Subfamily B, Member 3

Share to Cytotoxicity, Immunologic

Share to HLA-A2 Antigen

Share to Lymphocytes, Tumor-Infiltrating

Share to T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 10687135
DOI: 10.1097/00002371-200001000-00005

Genes

TAP1
TAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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