Article
Reduced recognition of metastatic melanoma cells by autologous MART-1 specific CTL: relationship to TAP expression.
Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jan 2000
Murray J L, Hudson J M, Ross M I, Zhang H Z, Ioannides C G
Abstract excerpt
Class I expression in context with T-cell receptor expression is crucial for peptide presentation and induction of CD8+ cytotoxic T lymphocytes (CTL). Presentation of class I bound peptides is dependent on transporter-associated proteins (TAP) expression and function. Tumor infiltrating lymphocytes from a patient with melanoma were isolated, expanded in vitro in the presence of interleukin-2, and tested for...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 2
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Abdominal Neoplasms
- Antigens, Neoplasm
- Cytotoxicity, Immunologic
- Female
- Gene Expression
- HLA-A2 Antigen