Article
Multiple HLA-A alleles can present an immunodominant peptide of the human melanoma antigen Melan-A/MART-1 to a peptide-specific HLA-A*0201+ cytotoxic T cell line.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 1996
Fleischhauer K, Tanzarella S, Wallny H J, Bordignon C, Traversari C
Abstract excerpt
The majority of HLA-A*0201-restricted tumor-infiltrating lymphocytes from melanoma patients recognize a peptide, MT(27-35), derived from the Melan-A/MART-1 Ag. This study reports that six variants of HLA-A2 and the HLA-A28 subtype A*6901 can present peptide MT(27-35). A CTL line specific for pept...
Topics
- Alleles
- Amino Acid Sequence
- Antigen Presentation
- Antigens, Neoplasm
- Cell Line
- HLA-A2 Antigen
- Humans
- Immunodominant Epitopes
- Lymphocyte Activation
- MART-1 Antigen
- Molecular Sequence Data
- Neoplasm Proteins
- Oligopeptides
- T-Lymphocytes, Cytotoxic