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Article

Susceptibility of human melanoma cells to autologous natural killer (NK) cell killing: HLA-related effector mechanisms and role of unlicensed NK cells.

PloS one - 4 Dec 2009

Carrega Paolo, Pezzino Gaetana, Queirolo Paola, Bonaccorsi Irene, Falco Michela, Vita Giuseppe, Pende Daniela, Misefari Aldo, Moretta Alessandro, Mingari Maria Cristina, Moretta Lorenzo, Ferlazzo Guido

Abstract excerpt

BACKGROUND: Despite Natural Killer (NK) cells were originally defined as effectors of spontaneous cytotoxicity against tumors, extremely limited information is so far available in humans on their capability of killing cancer cells in an autologous setting. METHODOLOGY/PRINCIPAL FINDINGS: We have established a series of primary melanoma cell lines from surgically resected specimens and here showed that human...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19997637
DOI: 10.1371/journal.pone.0008132
PMCID: PMC2780723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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