Article
Association of TP53 mutation, p53 overexpression, and p53 codon 72 polymorphism with susceptibility to apoptosis in adult patients with diffuse astrocytomas.
The International journal of biological markers - 1 Jan 2000
Uno M, Oba-Shinjo S M, Wakamatsu A, Huang N, Ferreira Alves V Avancini, Rosemberg S, de Aguiar Pires, Leite C, Miura F, Marino R Junior, Scaff M, Nagahashi-Marie S K
Abstract excerpt
Clarification of TP53 alterations is important to understand the mechanisms underlying the development of diffuse astrocytomas. It has been suggested that the alleles of TP53 at codon 72 differ in their ability to induce apoptosis in human cancers. The aim of this study was to analyze the possible association of TP53 mutation, p53 overexpression, and p53 codon 72 polymorphism with susceptibility to apoptosis in...
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