Article
TP53 mutations in astrocytic gliomas: an association with histological grade, TP53 codon 72 polymorphism and p53 expression.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Nov 2012
Faria Mario H G, Neves Filho Eduardo H C, Alves Markenia K S, Burbano Rommel M R, de Moraes Filho Manoel O, Rabenhorst Silvia H B
Abstract excerpt
TP53 mutations and polymorphisms have been widely related to many cancers as long as these alterations may impair its capacity to induce cell cycle arrest, DNA repair mechanisms, and apoptosis. Although TP53 alterations have been studied in astrocytic tumors, there is a lack of analysis considering specific TP53 mutations and their associations with p53 immunostainning, polymorphisms and their significance among...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Astrocytoma
- Biomarkers, Tumor
- Child
- Child, Preschool
- Codon
- DNA, Neoplasm
- Exons