Article
TP53 codon 72 polymorphism, p53 expression, and 1p/19q status in oligodendroglial tumors.
Cancer genetics and cytogenetics - 1 Sept 2007
Idbaih Ahmed, Boisselier Blandine, Marie Yannick, El Hallani Soufiane, Sanson Marc, Crinière Emmanuelle, Rodero Mathieu, Carpentier Catherine, Paris Sophie, Laigle-Donadey Florence, Ducray François, Hoang-Xuan Khê, Delattre Jean-Yves
Abstract excerpt
The functional single-nucleotide polymorphism (SNP) in codon 72 of TP53 has been shown to be both a risk factor and a prognostic biomarker in various cancers. Such results were also reported in brain tumors, notably in astrocytomas. This SNP has never been precisely investigated in oligodendroglial tumors. We retrospectively analyzed blood samples of 275 oligodendroglial tumor patients for the TP53 codon 72...
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