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Article

Epigenetic profiling of synchronous colorectal neoplasias by quantitative DNA methylation analysis.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Aug 2006

Ogino Shuji, Brahmandam Mohan, Kawasaki Takako, Kirkner Gregory J, Loda Massimo, Fuchs Charles S

Abstract excerpt

Transcriptional inactivation of tumor-suppressor genes by promoter CpG island methylation is thought to be an important mechanism in human carcinogenesis. The CpG island methylator phenotype (CIMP) with extensive promoter methylation appears to be a distinct epigenetic subtype of colorectal carci...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16699497
DOI: 10.1038/modpathol.3800618

Genes

BRAF
CRABP1
KRAS
MGMT
MLH1
NEUROG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16699497-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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