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Concordant DNA Methylation in Synchronous Colorectal Carcinomas

1 Sept 2009

Abstract excerpt

Epigenetic changes have been proposed as mediators of the field defect in colorectal carcinogenesis, which has implications for risk assessment and cancer prevention. As a test of this hypothesis, we evaluated the methylation status of eight genes (MINT1, 2, 31, MLH1, p16, p14, MGMT, and ESR1), as well as BRAF and KRAS mutations, in 57 multiple colorectal neoplasias (M-CRN) and compared these to 69 solitary...

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Share to Colorectal Cancer Screening and Detection
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PMID: 19737982
DOI: 10.1158/1940-6207.capr-09-0054

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