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Article

A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers.

Gastroenterology - 1 Nov 2009

Nosho Katsuhiko, Kure Shoko, Irahara Natsumi, Shima Kaori, Baba Yoshifumi, Spiegelman Donna, Meyerhardt Jeffrey A, Giovannucci Edward L, Fuchs Charles S, Ogino Shuji

Abstract excerpt

BACKGROUND & AIMS: Synchronous colorectal neoplasias (2 or more primary carcinomas identified in the same patient) are caused by common genetic and environmental factors and can be used to study the field effect. Synchronous colon cancers have not been compared with control solitary cancers in a prospective study. METHODS: We analyzed data collected from 47 patients with synchronous colorectal cancers and 2021...

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Source

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Identifiers

PMID: 19686742
DOI: 10.1053/j.gastro.2009.08.002
PMCID: PMC2859181

Genes

BRAF
CHFR
CRABP1
HIC1
IGF2
IGFBP3
KRAS
MGMT
MLH1
NEUROG1
RUNX3
SOCS1
WRN

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