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Article

Multiple sporadic colorectal cancers display a unique methylation phenotype.

PloS one - 1 Jan 2014

Gonzalo Victoria, Lozano Juan Jose, Alonso-Espinaco Virginia, Moreira Leticia, Muñoz Jenifer, Pellisé Maria, Castellví-Bel Sergi, Bessa Xavier, Andreu Montserrat, Xicola Rosa M, Llor Xavier, Ruiz-Ponte Clara, Carracedo Angel, Jover Rodrigo, Castells Antoni, Balaguer Francesc

Abstract excerpt

Epigenetics are thought to play a major role in the carcinogenesis of multiple sporadic colorectal cancers (CRC). Previous studies have suggested concordant DNA hypermethylation between tumor pairs. However, only a few methylation markers have been analyzed. This study was aimed at describing the epigenetic signature of multiple CRC using a genome-scale DNA methylation profiling. We analyzed 12 patients with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasms, Multiple Primary

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins B-raf

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Source

Open in PubMed Open full text

Identifiers

PMID: 24643221
DOI: 10.1371/journal.pone.0091033
PMCID: PMC3958343

Genes

BRAF
KRAS

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