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Article

Double knockouts. Production of mutant cell lines in cardiovascular research.

Hypertension (Dallas, Tex. : 1979) - 1 Oct 1993

Mortensen R M

Abstract excerpt

Double knockouts by homologous recombination is a method for producing cell lines with an inactivating mutation in any desired gene. The biochemical analysis of genetically altered cell lines has been important in determining the function of specific proteins. Until recently, mutant cell lines ha...

Topics

Alleles
Animals
Cardiology
Cardiovascular Physiological Phenomena
Cell Line
Genetic Techniques
Humans
Mice
Mice, Knockout
Mutation
Recombination, Genetic
Research

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Identifiers

PMID: 8406672
DOI: 10.1161/01.hyp.22.4.646

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8406672-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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