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Article

Double knockouts. Production of mutant cell lines in cardiovascular research.

Hypertension (Dallas, Tex. : 1979) - 1 Oct 1993

Mortensen R M

Abstract excerpt

Double knockouts by homologous recombination is a method for producing cell lines with an inactivating mutation in any desired gene. The biochemical analysis of genetically altered cell lines has been important in determining the function of specific proteins. Until recently, mutant cell lines have been produced by random mutagenesis and then selection for a particular phenotypic change. Recent technological...

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PMID: 8406672
DOI: 10.1161/01.hyp.22.4.646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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