Article
Biallelic gene knockouts in Chinese hamster ovary cells.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2008
Yamane-Ohnuki Naoko, Yamano Kazuya, Satoh Mitsuo
Abstract excerpt
Chinese hamster ovary (CHO) cells are the most common host cells and are widely used in the manufacture of approved recombinant therapeutics. They represent a major new class of universal hosts in biopharmaceutical production. However, there remains room for improvement to create more ideal host cells that can add greater value to therapeutic recombinant proteins at reduced production cost. A promising approach...
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