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Article

Targetted correction of a mutant HPRT gene in mouse embryonic stem cells.

Nature - 1 Jan 2000

Doetschman T, Gregg R G, Maeda N, Hooper M L, Melton D W, Thompson S, Smithies O

Abstract excerpt

Two recent developments suggest a route to predetermined alterations in mammalian germlines. These are, first, the characterization of mouse embryonic stem (ES) cells that can still enter the germline after genetic manipulation in culture and second, the demonstration that homologous recombination between a native target chromosomal gene and exogenous DAN can be used in culture to modify specifically the target...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 3683574
DOI: 10.1038/330576a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Targetted correction of a mutant HPRT gene in mouse embryonic stem cells.PMID 3683574Read ↗

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