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Article

Targetted correction of a mutant HPRT gene in mouse embryonic stem cells.

Nature - 1 Jan 2000

Doetschman T, Gregg R G, Maeda N, Hooper M L, Melton D W, Thompson S, Smithies O

Abstract excerpt

Two recent developments suggest a route to predetermined alterations in mammalian germlines. These are, first, the characterization of mouse embryonic stem (ES) cells that can still enter the germline after genetic manipulation in culture and second, the demonstration that homologous recombinatio...

Topics

Animals
Cell Line
Chromosome Deletion
DNA
Embryo, Mammalian
Genes
Humans
Hypoxanthine Phosphoribosyltransferase
Mice
Mutation
Promoter Regions, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 3683574
DOI: 10.1038/330576a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-3683574-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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