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Article

Use of gene targeting to study recombination in mammalian cell DNA repair mutants.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012

Rahn Jennifer J, Adair Gerald M, Nairn Rodney S

Abstract excerpt

The study of gene function has been greatly facilitated by the development of strategies to modify genomic DNA. Gene targeting is one of the most successfully applied techniques used to examine the roles of specific genes in a wide variety of model systems from yeast to mammals. Our laboratory has pioneered the use of the Chinese hamster ovary (CHO) cell culture model system to study pathways of DNA repair and...

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PMID: 22941622
DOI: 10.1007/978-1-61779-998-3_31

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APRT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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