Article
The stress-activated mitogen-activated protein kinase signaling cascade promotes exit from mitosis.
Molecular biology of the cell - 1 Jul 2006
Reiser Vladimír, D'Aquino Katharine E, Ee Ly-Sha, Amon Angelika
Abstract excerpt
In budding yeast, a signaling network known as the mitotic exit network (MEN) triggers exit from mitosis. We find that hypertonic stress allows MEN mutants to exit from mitosis in a manner dependent on the high osmolarity glycerol (HOG) mitogen-activated protein (MAP) kinase cascade. The HOG pathway drives exit from mitosis in MEN mutants by promoting the activation of the MEN effector, the protein phosphatase...
Topics
- Cell Cycle
- Enzyme Activation
- Fungal Proteins
- G1 Phase
- Glycerol
- Hypertonic Solutions
- MAP Kinase Signaling System
- Membrane Proteins
- Mitosis
- Mutation
- Osmotic Pressure