Article
Hog1 activation delays mitotic exit via phosphorylation of Net1.
Proceedings of the National Academy of Sciences of the United States of America - 21 Apr 2020
Tognetti Silvia, Jiménez Javier, Viganò Matteo, Duch Alba, Queralt Ethel, de Nadal Eulàlia, Posas Francesc
Abstract excerpt
Adaptation to environmental changes is crucial for cell fitness. In Saccharomyces cerevisiae, variations in external osmolarity trigger the activation of the stress-activated protein kinase Hog1 (high-osmolarity glycerol 1), which regulates gene expression, metabolism, and cell-cycle progression. The activation of this kinase leads to the regulation of G1, S, and G2 phases of the cell cycle to prevent genome...
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