Article
The stress-activated protein kinase Hog1 mediates S phase delay in response to osmostress.
Molecular biology of the cell - 1 Aug 2009
Yaakov Gilad, Duch Alba, García-Rubio María, Clotet Josep, Jimenez Javier, Aguilera Andrés, Posas Francesc
Abstract excerpt
Control of cell cycle progression by stress-activated protein kinases (SAPKs) is essential for cell adaptation to extracellular stimuli. Exposure of yeast to osmostress activates the Hog1 SAPK, which modulates cell cycle progression at G1 and G2 by the phosphorylation of elements of the cell cycle machinery, such as Sic1 and Hsl1, and by down-regulation of G1 and G2 cyclins. Here, we show that upon stress, Hog1...
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