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Article

The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes.

Nature - 22 Jan 2004

De Nadal Eulàlia, Zapater Meritxell, Alepuz Paula M, Sumoy Lauro, Mas Glòria, Posas Francesc

Abstract excerpt

Regulation of gene expression by mitogen-activated protein kinases (MAPKs) is essential for proper cell adaptation to extracellular stimuli. Exposure of yeast cells to high osmolarity results in rapid activation of the MAPK Hog1, which coordinates the transcriptional programme required for cell survival on osmostress. The mechanisms by which Hog1 and MAPKs in general regulate gene expression are not completely...

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Identifiers

PMID: 14737171
DOI: 10.1038/nature02258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Click a neighbor to travelStep 1 · 12 closest

The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes.PMID 14737171Read ↗

Recruitment of a chromatin remodelling complex by the Hog1 MAP kinase to stress genes.Semantic proximity Read ↗

Hog1 activation delays mitotic exit via phosphorylation of Net1.Semantic proximity Read ↗

Unique and redundant roles for HOG MAPK pathway components as revealed by whole-genome expression analysis.Semantic proximity Read ↗

Identifying protein kinase-specific effectors of the osmostress response in yeast.Semantic proximity Read ↗

The stress-activated protein kinase Hog1 mediates S phase delay in response to osmostress.Semantic proximity Read ↗

The Sch9 kinase is a chromatin-associated transcriptional activator of osmostress-responsive genes.Semantic proximity Read ↗

An integrated view on a eukaryotic osmoregulation system.Semantic proximity Read ↗

Rck2 kinase is a substrate for the osmotic stress-activated mitogen-activated protein kinase Hog1.Semantic proximity Read ↗

Transmembrane mucins Hkr1 and Msb2 are putative osmosensors in the SHO1 branch of yeast HOG pathway.Semantic proximity Read ↗

Structure and function of a transcriptional network activated by the MAPK Hog1.Semantic proximity Read ↗

Activation of the Saccharomyces cerevisiae filamentation/invasion pathway by osmotic stress in high-osmolarity glycogen pathway mutants.Semantic proximity Read ↗

Activation of the Hog1 MAPK by the Ssk2/Ssk22 MAP3Ks, in the absence of the osmosensors, is not sufficient to trigger osmostress adaptation in Saccharomyces cerevisiae.Semantic proximity Read ↗

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