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Article

Activation of the Saccharomyces cerevisiae filamentation/invasion pathway by osmotic stress in high-osmolarity glycogen pathway mutants.

Genetics - 1 Nov 1999

Davenport K D, Williams K E, Ullmann B D, Gustin M C

Abstract excerpt

Mitogen-activated protein kinase (MAPK) cascades are frequently used signal transduction mechanisms in eukaryotes. Of the five MAPK cascades in Saccharomyces cerevisiae, the high-osmolarity glycerol response (HOG) pathway functions to sense and respond to hypertonic stress. We utilized a partial loss-of-function mutant in the HOG pathway, pbs2-3, in a high-copy suppressor screen to identify proteins that modulate...

Topics

Cloning, Molecular
Genotype
Glycerol
Glycogen
Mitogen-Activated Protein Kinase Kinases
Mitogen-Activated Protein Kinases
Osmolar Concentration
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Signal Transduction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sorbitol

Suppression, Genetic

Transcription, Genetic

Source

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Identifiers

PMID: 10545444
DOI: 10.1093/genetics/153.3.1091
PMCID: PMC1460814

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-10545444-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Activation of the Saccharomyces cerevisiae filamentation/invasion pathway by osmotic stress in high-osmolarity glycogen pathway mutants.PMID 10545444Read ↗

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