Article
Activation of the Hog1 MAPK by the Ssk2/Ssk22 MAP3Ks, in the absence of the osmosensors, is not sufficient to trigger osmostress adaptation in Saccharomyces cerevisiae.
The FEBS journal - 1 Mar 2018
Vázquez-Ibarra Araceli, Subirana Laia, Ongay-Larios Laura, Kawasaki Laura, Rojas-Ortega Eréndira, Rodríguez-González Miriam, de Nadal Eulàlia, Posas Francesc, Coria Roberto
Abstract excerpt
Yeast cells respond to hyperosmotic stress by activating the high-osmolarity glycerol (HOG) pathway, which consists of two branches, Hkr1/Msb2-Sho1 and Sln1, which trigger phosphorylation and nuclear internalization of the Hog1 mitogen-activated protein kinase. In the nucleus, Hog1 regulates gene...
Topics
- Adaptation, Physiological
- Gene Expression Regulation, Fungal
- Glycerol
- MAP Kinase Kinase Kinases
- Mitogen-Activated Protein Kinases
- Mutation
- Osmolar Concentration
- Osmotic Pressure
- Phosphorylation
- Saccharomyces cerevisiae