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An Association between Reduced Susceptibility to Daptomycin and Reduced Susceptibility to Vancomycin in Staphylococcus aureus

2 May 2006

Abstract excerpt

To THE EDITOR—Daptomycin, a novel lipopeptide antimicrobial agent, is being used with increasing frequency for managing infections caused by drug-resistant, gram-positive bacteria with reduced susceptibility to vancomycin (including Staphylococcus aureus) [1]. Daptomycin has a unique mechanism of action, which includes Ca2+-dependent insertion of the agent into bacterial cytoplasmic membranes. Because the...

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PMID: 16652325
DOI: 10.1086/504084

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