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Article

In vitro cross-resistance to daptomycin and host defense cationic antimicrobial peptides in clinical methicillin-resistant Staphylococcus aureus isolates.

Antimicrobial agents and chemotherapy - 1 Sept 2011

Mishra Nagendra N, McKinnell James, Yeaman Michael R, Rubio Aileen, Nast Cynthia C, Chen Liang, Kreiswirth Barry N, Bayer Arnold S

Abstract excerpt

We investigated the hypothesis that methicillin-resistant Staphylococcus aureus (MRSA) isolates developing reduced susceptibilities to daptomycin (DAP; a calcium-dependent molecule acting as a cationic antimicrobial peptide [CAP]) may also coevolve reduced in vitro susceptibilities to host defense cationic antimicrobial peptides (HDPs). Ten isogenic pairs of clinical MRSA DAP-susceptible/DAP-resistant...

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Identifiers

PMID: 21709105
DOI: 10.1128/AAC.00223-11
PMCID: PMC3165344

Genes

DAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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