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Article

Mechanisms of in-vitro-selected daptomycin-non-susceptibility in Staphylococcus aureus.

International journal of antimicrobial agents - 1 Nov 2011

Patel Diixa, Husain Mashkur, Vidaillac Celine, Steed Molly E, Rybak Michael J, Seo Susan M, Kaatz Glenn W

Abstract excerpt

Daptomycin is highly active against Staphylococcus aureus, including multidrug-resistant strains and those with reduced susceptibility to vancomycin. However, daptomycin-non-susceptible (Dap(NS)) strains [minimum inhibitory concentration (MIC) >1mg/L] have been derived clinically and in vitro. The mechanism(s) by which this occurs is incompletely understood, but existing data indicate that it is multifactorial....

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Source

Identifiers

PMID: 21840181
DOI: 10.1016/j.ijantimicag.2011.06.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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