Article
Cells expressing murine RAD52 splice variants favor sister chromatid repair.
Molecular and cellular biology - 1 May 2006
Thorpe Peter H, Marrero Vanessa A, Savitzky Margaret H, Sunjevaric Ivana, Freeman Tom C, Rothstein Rodney
Abstract excerpt
The RAD52 gene is essential for homologous recombination in the yeast Saccharomyces cerevisiae. RAD52 is the archetype in an epistasis group of genes essential for DNA damage repair. By catalyzing the replacement of replication protein A with Rad51 on single-stranded DNA, Rad52 likely promotes strand invasion of a double-stranded DNA molecule by single-stranded DNA. Although the sequence and in vitro functions of...
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