Article
Targeted inactivation of mouse RAD52 reduces homologous recombination but not resistance to ionizing radiation.
Molecular and cellular biology - 1 Nov 1998
Rijkers T, Van Den Ouweland J, Morolli B, Rolink A G, Baarends W M, Van Sloun P P, Lohman P H, Pastink A
Abstract excerpt
The RAD52 epistasis group is required for recombinational repair of double-strand breaks (DSBs) and shows strong evolutionary conservation. In Saccharomyces cerevisiae, RAD52 is one of the key members in this pathway. Strains with mutations in this gene show strong hypersensitivity to DNA-damagin...
Topics
- Animals
- B-Lymphocytes
- Cell Survival
- DNA Damage
- DNA Repair
- DNA-Binding Proteins
- Flow Cytometry
- Immunoglobulin Switch Region
- Mice
- Mice, Knockout
- Phenotype
- Rad52 DNA Repair and Recombination Protein
- Radiation, Ionizing
- Recombination, Genetic
- Saccharomyces cerevisiae