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Article

Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination.

Cell - 18 Apr 1997

Essers J, Hendriks R W, Swagemakers S M, Troelstra C, de Wit J, Bootsma D, Hoeijmakers J H, Kanaar R

Abstract excerpt

Double-strand DNA break (DSB) repair by homologous recombination occurs through the RAD52 pathway in Saccharomyces cerevisiae. Its biological importance is underscored by the conservation of many RAD52 pathway genes, including RAD54, from fungi to humans. We have analyzed the phenotype of mouse R...

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Source

Identifiers

PMID: 9108475
DOI: 10.1016/s0092-8674(00)80199-3

Genes

RAD52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9108475-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination.PMID 9108475Read ↗

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The Drosophila melanogaster DmRAD54 gene plays a crucial role in double-strand break repair after P-element excision and acts synergistically with Ku70 in the repair of X-ray damage.Semantic proximity Read ↗

Human and mouse homologs of the Saccharomyces cerevisiaeRAD54 DNA repair gene: evidence for functional conservationSemantic proximity Read ↗

Reduced X-ray resistance and homologous recombination frequencies in a RAD54-/- mutant of the chicken DT40 cell line.Semantic proximity Read ↗

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Reappearance from Obscurity: Mammalian Rad52 in Homologous RecombinationSemantic proximity Read ↗

The enigmatic oncogene and tumor suppressor‐like properties of RAD54B: Insights into genome instability and cancerSemantic proximity Read ↗

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