Article
Rad51C is essential for embryonic development and haploinsufficiency causes increased DNA damage sensitivity and genomic instability.
Mutation research - 7 Jul 2010
Smeenk Godelieve, de Groot Anton J L, Romeijn Ron J, van Buul Paul P W, Zdzienicka Malgorzata Z, Mullenders Leon H F, Pastink Albert, Godthelp Barbara C
Abstract excerpt
Homologous recombination is essential for repair of DNA interstrand cross-links and double-strand breaks. The Rad51C protein is one of the five Rad51 paralogs in vertebrates implicated in homologous recombination. A previously described hamster cell mutant defective in Rad51C (CL-V4B) showed increased sensitivity to DNA damaging agents and displayed genomic instability. Here, we identified a splice donor mutation...
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