Article
Mouse RAD54 affects DNA double-strand break repair and sister chromatid exchange.
Molecular and cellular biology - 1 May 2000
Dronkert M L, Beverloo H B, Johnson R D, Hoeijmakers J H, Jasin M, Kanaar R
Abstract excerpt
Cells can achieve error-free repair of DNA double-strand breaks (DSBs) by homologous recombination through gene conversion with or without crossover. In contrast, an alternative homology-dependent DSB repair pathway, single-strand annealing (SSA), results in deletions. In this study, we analyzed the effect of mRAD54, a gene involved in homologous recombination, on the repair of a site-specific I-SceI-induced DSB...
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