Article
Exploring the diabetogenicity of the HLA-B18-DR3 CEH: independent association with T1D genetic risk close to HLA-DOA.
Genes and immunity - 1 Sept 2009
Santin I, Castellanos-Rubio A, Aransay A M, Gutierrez G, Gaztambide S, Rica I, Vicario J L, Noble J A, Castaño L, Bilbao J R
Abstract excerpt
The objective of this study was to identify additional diabetes susceptibility markers in the MHC that could be responsible for the differential diabetogenicity of different HLA-DR3 CEHs. High-resolution SNP genotyping of the MHC was carried out in 15 type 1 diabetes (T1D) patients and 39 non-diabetic controls, homozygous for DR3-DQ2 and with one copy of the...
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