Article
Toward understanding MHC disease associations: partial resequencing of 46 distinct HLA haplotypes.
Genomics - 1 May 2006
Smith Wade P, Vu Quyen, Li Shuying Sue, Hansen John A, Zhao Lue Ping, Geraghty Daniel E
Abstract excerpt
We carried out a resequencing project that examined 552 kb of sequence from each of 46 individual HLA haplotypes representing a diversity of HLA allele types, generating nearly 27 Mb of fully phased genomic sequence. Haplotype blocks were defined extending from telomeric of HLA-F to centromeric of HLA-DP including in total 5186 MHC SNPs. To investigate basic questions about the evolutionary origin of common HLA...
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