Article
SNP profile within the human major histocompatibility complex reveals an extreme and interrupted level of nucleotide diversity.
Genome research - 1 Oct 2000
Gaudieri S, Dawkins R L, Habara K, Kulski J K, Gojobori T
Abstract excerpt
The human major histocompatibility complex (MHC) is characterized by polymorphic multicopy gene families, such as HLA and MIC (PERB11); duplications; insertions and deletions (indels); and uneven rates of recombination. Polymorphisms at the antigen recognition sites of the HLA class I and II genes and at associated neutral sites have been attributed to balancing selection and a hitchhiking effect, respectively....
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