Article
Microsatellite typing for DRB1 alleles: application to the analysis of HLA associations with rheumatoid arthritis.
Genes and immunity - 1 Oct 2006
Lee H-S, Li W, Lee A, Rodine P, Graham R R, Ortmann W A, Batliwalla F, Lee K W, Bae S C, Behrens T W, Gregersen P K
Abstract excerpt
The current methods for molecular typing of HLA-DR alleles incur a substantial financial burden when performing large population studies. In the current study, we aimed to provide much less expensive typing approach with high predictability for DRB1 genotype. We have used a panel of three microsatellite markers in the class II region (D6S2666, D6S2665 and D6S2446) for genotyping and haplotype reconstruction in a...
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