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Next Generation Sequencing Identifies the HLA-DQA1*03:03 Allele in the Type 1 Diabetes Risk-Associated HLA-DQ8 Serotype.

Genes - 25 Nov 2021

Enczmann Jürgen, Balz Vera, Hoffmann Maximilian, Kummer Sebastian, Reinauer Christina, Döing Carsten, Förtsch Katharina, Welters Alena, Mayatepek Ertan, Meissner Thomas, Jacobsen Marc, Seyfarth Julia

Abstract excerpt

The highest genetic type 1 diabetes risk is conferred by HLA class II haplotypes defined by alleles at the HLA-DR and -DQ loci. The combination of HLA-DQA1*03:01 and DQB1*03:02 alleles (summarized as 'HLA-DQ8') is reported to be among the two most prevalent HLA class II haplotypes in Caucasian type 1 diabetes patients. This classification is based on conventional genotyping of exon 2 of the DQ gene locus and...

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Identifiers

PMID: 34946827
DOI: 10.3390/genes12121879
PMCID: PMC8701008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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